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39,40 These effects have made it a subject of interest in longevity medicine

The occurrence of ferroptosis depends on multiple parallel and coupled molecular pathways, and the role of GPX4 within them is strictly constrained by upstream reductive systems, lipid substrate sources, and alternative antioxidant networks

The alternative secretagogues lack this level of validation

Makarcyzk, Hang Lin Publication Date: April 2021 Tools to eliminate senescent cells Another important reference comes from a 2017 article in Nature, which discusses various tools for eliminating senescent cells, including FOXO4-DRI