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By employing a -adrenergic receptor blocker and a ghrelin receptor antagonist, they discovered that the oral intake of hydrogen water activates the -adrenergic receptor signaling pathway in the stomach, inducing ghrelin secretion, which in turn protects dopaminergic neurons in MPTP-induced PD model mice

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Discovery of direct inhibitors of Keap1Nrf2 proteinprotein interaction as potential therapeutic and preventive agents

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