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Reduced tumor burden and decreased expression of metastasis markers, p-IGF1R and p-ERK1/2, as well as changes in IGF system gene expression in lungs of IGF1R-deficient mice To evaluate the effect of IGF1R depletion on LLC metastasis, tumor burden, metastasis markers, p-IGF1R, p-ERK1/2 and IGF system gene expression were assessed in lungs of IGF1R-deficient ( CreERT2 ) mice vs

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A large review (56) noted that three studies estimated the narrow-sense heritability (h 2 ) in large cohorts, and two of these studies reported non-zero results, suggesting a heritability risk for ME/CFS