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While the gold standard for interventional studies is a placebo-controlled, double-blind, randomized trial, this is often impractical for rare diseases, mostly due to the extremely low prevalence and geographical scattering of patients [256]

If you have sensitive skin or underlying conditions, starting with less frequent treatments and monitoring your skins response is recommended

Results The area under the time concentration curve (AUC 0-t ) was lower after SC (398 155 ng/mL/min) than IM (696 168 ng/mL/min, p 6 ng/mL for 4 h, with a t of 233 min [10]