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doi: 10.3389/fnins.2026.1736978 Received 31 October 2025 Revised 24 January 2026 Accepted 03 February 2026 Published 04 March 2026 Volume 20 - 2026 Edited by Charles N

Store at 20 to 25C (68 to 77F) [see USP Controlled Room Temperature]

Dialed-In Sleep Timing Melatonin signals your body that it's time to sleep, helping you fall asleep faster and stay on a natural rhythm especially useful during heavy training blocks, travel, or after late-night events

Interestingly, compared with sedentary controls, bone marrow-derived macrophages (BMDMs) from exercise-trained mice show reduced LPS-induced NF-B activation and proinflammatory gene expression, along with increased expression of M2-related genes, these changes are associated with improved mitochondrial quality, increased reliance on oxidative phosphorylation, and reduced ROS production (35, 36)