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In an early trial, a population with equally distributed pre-menopausal and post-menopausal status only including pre-treatment cases (chemotherapy with or without radiotherapy and/or hormonotherapy) with metastatic disease (skin 36%, lymph nodes 34%, bone 42%, and visceral 97%) underwent PTX 135 mg/m 2 versus 175 mg/m 2 infusion over 3 h every 3 weeks