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Arias, T., & Gordon, M

Tertiary structure of the major house dust mite allergen Der p 2: sequential and structural homologies

Exceptional safety margin No dependence or tolerance naturally occurring endogenous peptide Tolerability in clinical trials No tolerance develops with repeated doses No withdrawal symptoms upon stopping Peptide naturally present in the human body Research considerations Researcher's notes Outstanding safety profile for a bioactive peptide No serious adverse events were reported in the published studies

The practical difference between single and split dosing remains unclear from available research, so personal experimentation within recommended total daily doses is reasonable