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Hussein and collaborators recently reported lowered levels of IGF-1 in the skin and blood of vitiligo patients compared to reference samples, confirming the systemic nature of vitiligo ( 7.4 Mitochondria-targeted therapy for vitiligo Existing data suggest that mitochondrial dysfunction plays a causative role in the development and progression of vitiligo

RACK1 is an insulin-like growth factor 1 (IGF-1) receptor-interacting protein that can regulate IGF-1-mediated Akt activation and protection from cell death

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Site of reactivity data is nearly unstudied in the literature prior to our efforts, yet contains a strong signal for reactivity that can be utilized to more accurately predict molecule reactivity and, eventually, toxicity