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C-terminal amidation, as seen in Nle-Tyr-Ile-His-NH, also provided a more modest increase in stability

Cialis (Tadalafil) for BPH Brand name: Cialis Dose: Typically 5 mg daily FDA-approved for both erectile dysfunction and BPH How it works: Relaxes muscle in the prostate and bladder, improving urine flow Efficacy: Improves International Prostate Symptom Score (IPSS) by ~45 points vs placebo Subjectively improves feeling of obstruction, minimal quantitative improvement objectively Onset may be slower than alpha-blockers but benefits both urinary symptoms and sexual function Side Effects: Headache Back pain Indigestion Rare: visual changes, priapism (prolonged erection) Note: Cialis is often ideal for men with both BPH and ED

REDEFINE 2 showed 13.7% in T2D patients at 68 weeks