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The expansion of the polyQ tract and change in conformation of ATXN3 was reported to alter transcriptional activity in cells by impairing repressor activity, when compared with wild-type ATXN3, of the MMP-2 gene promoter [115], and by reducing capability to activate FOXO-mediated SOD2 expression during oxidative stress [116]
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Specific volumes, target concentrations, and dose calculations cited in non-clinical or informal sources are not derived from authoritative data and may be inaccurate, unsafe, or based on products of unknown quality and purity
