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Excessive secretion of zonulin causes prolongation of the opening time of TJ, which can prolong the abnormal activation of the immune system over time [16, 18, 70,71,72]

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Antioxidant and anti-inflammatory effect GHK-Cu acts as a scavenger of free radicals : Captures hydroxyl radicals (OH) Inhibits lipid peroxidation Stimulates endogenous antioxidant defense (SOD, glutathione peroxidase) In the anti-inflammatory area it modulates NF-B signaling , the key transcription factor of the inflammatory response

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