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Individuals with higher oxidative stress levels, significant sun exposure history, or hormonal pigmentation may require longer treatment durations

A final consideration is that second messenger-dependent protein kinases could phosphorylate other proteins, which subsequently influence GPCR desensitization, such as regulator of G protein signalling proteins (Cunningham et al ., 2001) or the Raf kinase inhibitor protein, which upon PKC phosphorylation becomes able to inhibit GRK2 function and hence -AR desensitization (Lorenz et al ., 2003)

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PLoS Med 14, e1002261.Google Scholar Foster, TC, DeFazio, RA, Bizon, JL