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Studies have also proposed a role in ryanodine receptor modulation, interleukin-1 (IL-1) secretion and endoplasmic reticulum stress-mediated autophagy 7,12,13,14,15
The majority of patients survive acetaminophen toxicity with supportive care such as intravenous fluids and anti-nausea medication, activated charcoal, if used within one hour after ingestion, and antidotal therapy, including N-acetylcysteine [13]
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A comparison between the apo- and Cu I -bound states suggests a mechanism of allosteric connectivity where the metal binding event induces a kink in the 2 helix, which leads to a rearrangement of surface electrostatic potential distribution, thus driving DNA dissociation and transcriptional derepression of Cu I -resistance genes
