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This deficiency is particularly concerning as glutathione is vital for various physiological processes, including cellular protection and detoxification

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Our finding that several diseases show lowered blood NAD + levels and overall imbalanced redox metabolites is intriguing, as it suggests that a variety of disease processes increase NAD + usage, potentially by activated repair processes including PARP enzymes a major user of NAD +8 .The results have high potential relevance for clinical and research applications, follow-up of metabolic interventions and detection of disease-induced NAD + or glutathione deficiency to select patients for treatment

This may indicate the effects of adverse, external conditions on cellular homeostasis or disorders of the internal functioning of the organism (Pastore et al