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Dose optimization, dietary adjustments, and exercise modifications typically produce better results than adding unvalidated combination protocols

In contrast, DIO mice in both groups switched from WD to LD each had significantly increased Proteobacteria relative abundance (represented solely by the genus Parasutterella ) compared to both the WD and the LD controls, suggesting that Proteobacteria relative abundance may be largely influenced by stress or the differences in net energy expenditure (or associated body weight changes) caused by the diet switch

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A Vitamin B12 deficiency can lead to weight changes, although the effects can vary from person to person