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While paracellular transmigration involves passage through intercellular junctionsoften exacerbated by disrupted tight junctions under pathological conditionstranscellular transport is facilitated by various endocytic mechanisms, such as clathrin-mediated endocytosis, macropinocytosis, and lipid raft-dependent pathways 157,158,159,160,161

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At the gastric level, cagrilintide significantly slows gastric emptying and food transit through the gastrointestinal tract

Phosphorylation of eIF2 leads to inhibition of general protein synthesis, but paradoxically increases the translation of selective mRNA such as ATF4 16