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2 Current status and advances in cohort studies of high altitude illness populations Cohort studies, due to their exceptional ability to unravel complex interplays between compounded exposures such as high-altitude environments, lifestyle habits, and genetic components with health outcomes, have been universally recognized as a preeminent research approach in exploring etiological mechanisms and formulating strategies for disease prevention and management ( Li and Lyu, 2015 )

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Smoking-induced OS activates inflammation and initiates ROS production