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These effects have been attributed to the regulation of the gut microbiota, which may influence pain, depression, sleep quality, and overall cognitive and emotional status in people with FM

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Symptoms of B12 deficiency include: Low energy and fatigue Digestive problems Depression and moodiness Insomnia Brain fog and memory loss Anemia Reduced immune system function Tingling or numbness in the extremities Swollen tongue Loss of vision or hearing Jaundice Kidney disease Pale skin Poor circulation in the extremities If you are over age 50 and are experiencing one or more of the above symptoms, boosting your intake of B12 cannot hurt, and it may provide a safe and inexpensive solution while preventing a wrong diagnosis

Intramuscular (IM) injection is the most invasive and costly administration method, requiring trained personnel and clinical visits