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This group, which includes polyquinones, naphthoquinones, and anthraquinones, exhibits a wide range of biological activities such as antioxidant, anti-inflammatory, and immunomodulatory effects

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344,345,346 Although some studies indicate that breast cancer patients with ER expression between 1% and 10% may exhibit reduced sensitivity to endocrine therapy, the threshold of 1% ER expression is still used in most current clinical practices to determine the need for endocrine therapy