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This MMP-1 inhibition occurs through interference with AP-1 transcription factor binding to the MMP-1 promoter region, reducing collagen degradation rates in dermal matrices

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In patients with refractory IBD, co-administration of anti-TNFs with vedolizumab, ustekinumab or natalizumab has shown promising results in case reports and case series and was not accompanied by a substantial increase in the incidence of serious adverse events, such as serious infections [203]

This highlights age as a significant risk factor for non-healing, a reality that can feel discouraging