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Second, the jump from 8 mg to 12 mg produced only 1 percent additional benefit

As demonstrated by Sugino et al., estrogen and progesterone withdrawal at the end of the secretory phase may upregulate ROS and downregulate SOD, with the former triggering a sequential cascade that starts by activating nuclear factor kappa-light chain enhancer of activated B cells (NF-B) and cyclooxygenase-2 and ends with prostaglandin F 2 production, culminating in endometrial shedding [17]

Additionally, PEs, located in the inner layer of the cell membrane, frequently interact with Fe 2+ , which catalyzes the fenton reaction, producing highly reactive hydroxyl radicals (OH) that readily oxidize AA and AdA