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In addition, it is thought that the mechanisms that ensure PQC in the nucleus are distinct from those of other organelles [108, 109], an example being the exclusive use of K48-linked ubiquitin chains required for proteasomal degradation of misfolded proteins, and thus independency of K11-specific ligases and chaperones [110]
Together, these two mechanisms seem to work jointly to enhance ROS levels and lead to cell death in cisplatin-resistant lung cancer cells
You might be using a solution you think is at a specific concentration, but in reality, it could be 50% or less of its original strength
Without clear diagnostic criteria, clinical trials comparing glutathione to placebo in this population have not been conducted
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