acetyl l carnitine glutamate The protective effect of L-carnitine on testosterone synthesis pathway, and spermatogenesis in monosodium glutamate-induced rats | BMC Complementary Medicine and Therapies Acetyl-L-Carnitine in Neuropathic Pain |

The sprout extract of Tuscan black cabbage, a type of kale, was found to be protective against a high-fat diet in rats, restoring antioxidant and phase II enzyme levels and lowering serum lipids (total cholesterol, triacylglycerides, non-esterified fatty acids) (Melega et al., 2013)

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In detail, ROS are involved in disturbing antioxidant defenses, the mitochondria, microtubule, ion channels, and biomolecular functions, as well as inducing neuroinflammation, demyelination, and neuronal apoptosis in the process of PIPN ( Pt-induced ROS production easily breaks the balance of endogenous ROS and cellular antioxidant systems to trigger oxidative stress and mitochondrial dysfunction, resulting in the damage or loss of DRG cells containing abundant ROS-sensitive phospholipids ( Regarding ion channels, TRP play a key role in aggravating cold abnormal pain, among which, TRPA1 and transient receptor potential melastatin 8 (TRPM8), as cold-sensitive receptors, could be activated by ROS (Shimizu et al., 2014