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Compound 28 is a new quinoxaline-2,3-dione derivative synthesized from N-[2,3-dioxo-6-(phenylethynyl)-3,4-dihydroquinoxalin-1(2H)-yl] benzamide as a lead structure, which is a competitive GluK3 antagonist with sub-micromolar affinity and unprecedentedly high binding selectivity, with 400-fold higher selectivity for GluK3 than for other cognate receptors, and no agonistic or antagonistic activity in mGluRs isoforms [186]