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SFN is able to react with the thiol groups of Keap 1 and form thionacyl adducts promoting Nrf2 dissociation from Keap1 and subsequent activation of ARE driven gene expression and this may explain the increased GSH levels measured in control cells following SFN treatment

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Aside from its clinical benefits, Zealand has also touted the chemical and physical stability of petrelintide, according to the Leerink analysts, which in turn could make the investigational drug a good candidate for other therapeutic peptides in a single solution

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