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Nevertheless, antidepressants posed a risk of altering gut flora in several animal models via inhibition of efflux pumps and/or amino acid transporters, which may exacerbate issues related to inflammation and immune responses [193,194,195,196,197]

Yet most would still agree that the delicate interplay of neurotransmitters in an individual patient suffering from depression is not always easy to interpret or treat

doi: 10.1016/j.bbagen.2015.09.001

Notably, AFG pretreatment enhanced recovery from renal injury by alleviating OS, mediating NF-B-related inflammation, and inhibiting the PI3K/Akt apoptotic signaling pathways