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Additionally, these microglia displayed abnormal characteristics, such as enlarged cell bodies and shortened processes

Briefly, a full-thickness cartilage defect (2 mm in diameter and 2.0 mm in depth) was created in the center of the trochlear groove with an electric bone drill in both knees of 4-week-old SD rats

Loss of neuronal GSH has also been linked to microglial activation and complement-mediated neurodegeneration, further emphasizing the link between redox imbalance and immune dysregulation (Hashimoto et al., 2023)