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One of the triggers of Ca 2+ release from the brain mitochondria can be perisynaptic ATP bound to astrocyte receptors

Astrocytes play a central role in maintaining CNS homeostasis through purinergic signaling, wherein extracellular ATP and its degradation product adenosine modulate synaptic activity, inflammation, and neuronal excitability via purinergic P2X, P2Y, and adenosine receptors [324, 326]