Diesen Aspekt haben wir in den letzten Monaten deutlich vertieft und die Ergebnisse waren teilweise berraschend
Would lab testing, stool testing, inflammatory markers, or specialist referral be appropriate
The role of the intestinal mycobiota is under investigation, and the importance of the fungal fraction of the gut can be demonstrated in IBD by a CD biomarker ASCA antibody (anti- Saccharomyces cerevisiae )
The diagnostic process typically involves: Clinical history taking, focusing on symptoms (fatigue, neurological changes, dietary habits) Physical examination for signs of anaemia or neurological impairment Blood tests including full blood count, serum B12, and often folate levels Additional investigations such as intrinsic factor antibodies or parietal cell antibodies if pernicious anaemia is suspected For borderline results, additional tests like holotranscobalamin (active B12) may be considered NICE guidance recommends that treatment should commence based on clinical presentation if neurological symptoms are present, without waiting for laboratory confirmation, as delays can result in irreversible nerve damage
