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Andreone BJ, Chow BW, Tata A, Lacoste B, Ben-Zvi A, Bullock K, et al

The molecule has been studied in animal models of adipose-tissue metabolism, with published preclinical work examining its effects on NAD+ pool dynamics and on the methyl-donor balance NNMT regulates

Reactive nitrogen species arise primarily from the metabolism of nitric oxide (NO), a signalling molecule synthesized from arginine by nitric oxide synthases [29]

Were excited that these data, the first phase 3 data of a next-generation amylin therapy, show promise and we look forward to further investigating cagrilintides potential in the dedicated phase 3 RENEW programme. * Based on the trial product estimand