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Research in rat pinealocytes showed that epitalon upregulates two key enzymes in the melatonin synthesis pathway AANAT and pCREB directly stimulating endogenous melatonin production at the cellular level

Arch Environ ContamToxicol 64:235242 Dixit G, Singh AP, Kumar A, Dwivedi S, Deeba F, Kumar S, SumanS AB, Shukla Y, Trivedi PK, Pandey V, Norton GJ, Dhankher OP, Tripathi RD (2015) Sulfur alleviates arsenic toxicity by reducing its accumulation and modulating proteome, amino acids and thiol metabolism in rice leaves

Plus, it can also be served up as an oral supplement to target uneven skin tone

Role of flavonoids in neurodegenerative disorders with special emphasis on tangeritin