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NAE conceptualized the manuscript

This broader injectable culture, with simultaneous increases in steroid use, may be lowering barriers to more experimental practices, including peptide use

Sulfate conjugation reactions catalyzed by SOT generate 3-phosphoadenosine 5-phosphate (PAP), a molecule that participates in the organelle-nuclear retrograde signaling, if not dephosphorylated by the SAL1 phosphatase ( FIGURE 1 While many essential steps of the sulfate assimilation and cysteine, methionine and glutathione biosynthesis pathways occur exclusively in plastids, a few enzymes present in the cytosol and mitochondria also come into play, which necessitates a concerted action between enzymes present in different subcellular compartments and intracellular transporters