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It causes painful swelling that can eventually result in bone loss and joint deformity

Individuals reporting very frequent cannabis use (50+ times by late teens) have up to a sixfold higher odds of a schizophrenia diagnosis in adulthood compared to individuals without substance use 48

Selective migration to western countries may also contribute to a higher prevalence of psychosis

Categorical tobacco and cannabis co-use is not significantly associated with higher risk of conversion to psychosis When we defined tobacco and cannabis use categorically (no use, tobacco use only, cannabis use only, co-use), co-use of cannabis and tobacco was associated with higher risk of conversion compared to no use of either substance (HR = 1.69, 95% CI [0.962.97], P = 0.070, Supplementary Fig