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A second important turning point in the field, with novel therapeutic implications, is the appreciation that chronicity may emerge from persistent and exacerbated pro-inflammatory signals as well as from the failure of the resolution pathways, a concept now well accepted for example to explain the chronicity of rheumatoid arthritis where aggressive fibroblasts are key players (135)

This method allows for the simultaneous measurement of various cellular characteristics, making it highly efficient for complex analyses

Patients frequently describe this cognitive dysfunction as "brain fog"a terrifying sensation where memories slip away, words become impossible to find, and concentration shatters

IFN- may be an important mediator of MASH progression