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In contrast, phosphorylation of STAT3, SMAD3, and STAT5 was not detected under the same conditions in nave CD4 T cells isolated from Gpr15 / mice, highlighting the essential role of GPR15 in CSE-induced activation of these signaling pathways during CD4 T-cell differentiation (Supplementary Fig

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A warning relates to the IHL obligation to give advanced and effective warning of impending targeted attacks that might affect a civilian population, unless the situation does not permit it.[47] The primary purpose of advance warnings is to allow civilians sufficient time to leave an area or take cover to reduce civilian casualties and damage to civilian objects