Additionally, since the prostate gland secretes fluids that contribute to semen, and seminal fluid is deposited in the prostatic urethra by the vas deferens, PCa can result in difficulties achieving an erection, painful ejaculation, and other sexual dysfunctions
The therapeutic intent does not matter
This dependency is not limited to MYC-driven tumor cells but also occurs in various other cancer cell lines, including lymphomas, prostate cancer, osteosarcoma, renal cell carcinoma, colorectal cancer, and small cell lung cancer [84, 86,87,88,89,90].These tumor cells rely on glutamine for cell survival and growth when MYC is activated
No human safety data : The complete absence of human clinical trials means the safety profile, side effects, optimal dosing, and pharmacokinetics in humans are entirely unknown Animal-to-human translation is uncertain : Metabolic differences between mice and humans mean that the magnitude of effects (e.g., weight loss, grip strength improvement) may not translate