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Corticosteroneinduced depressionlike behaviors are associated with hippocampal apoptosis and suppressed cAMP expression [24], consistent with reports of impaired cAMP signaling in chronic stress [25]

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In some embodiments, the otic formulation or composition comprises about 0.7% by weight of the cholesterol

Oxidative stress plays an important role in the pathogenesis of a variety of autoimmune diseases and many environmental agents participate in this process