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19 We speculate that patients with clEDS may be more prone to have structural defects along the walls of the gastrointestinal tract, which can predispose to diffuse diverticulosis, diverticulitis, and resulting bowel perforation as well as to perforation during invasive procedures and spontaneous perforation

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Our analyses also indicate such signaling mitigates, but does not override the negative regulation of adult neurogenesis when IH is experienced over the entire period of development from NSCs to neuronal fate