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The primary endpoint, a blinded assessment of the percentage over target (that is, time with dyskinesia or bradykinesia), recorded by home actimetry using a wristwatch, was significantly reduced on A-dopamine compared with that on oral treatment alone ( P = 0.027), with a median within-patient difference of 10.4 (Hedge g = 0.62 (95% confidence interval: 1.43, 0.08))

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The other three components work at lower concentrations, which is why they appear at 10mg each

According to the UK government, our bodies require 1.5 micrograms (mcg) a day of Vitamin B12, although other governments advise that we actually need more