#EvidenceBased #ScienceCommunication #WellnessCulture #Supplements #Peptides #HealthCanada #MedicalMisinformation #InformedConsent #SportsScience #Skepticism In response to a private message: Why are there not more (any) human RCTs
Oral Administration Most peptides cannot survive oral delivery the sequential barriers of stomach acid, intestinal enzymes, and first-pass liver metabolism degrade peptide bonds before they reach systemic circulation
AhR activation can inhibit inflammasome (such as NLRP3) activation, reduce the production of pro-inflammatory factors like IL-1, and promote IL-22 secretion, which has a protective effect on hepatocytes and can reduce oxidative stress and steatosis
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