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Large amounts of B12 can potentially interact with some drugs used for diabetes, heartburn, seizures, and more

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They tested these inhibitors in cell and animal models. They reported changes in intracellular nicotinamide-related metabolites and examined the biological effects of NNMT inhibition under experimental conditions. These outcomes have increased scientific interest in NNMT biology

therefore, calcium supplementation is not currently prescribed for the prevention or treatment of metformin-induced vitamin B 12 deficiency (145)