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The search terms included irritable bowel syndrome, microbiota, microbiome, and IBS treatment. These search items were combined with the AND operator to additional search terms for the relevant sections of the review, including pathophysiology, animal studies, metagenomics, prebiotics, probiotics, fecal transplantation, symbiotic, postbiotic, metagenome, fungal treatment, archaebiotics, phage therapy, 3-D gut modeling, dietary intervention, pathogenesis, FODMAP, diet, meta-analysis, and future therapy. All authors contributed toward the literature search