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Nevertheless, use of metformin may decrease vitamin B 12 status: a meta-analysis of four short-term intervention trials (up to 4 months duration) in patients with type 2 diabetes found that metformin use decreased serum cobalamin concentrations by 57 pmol/L, which could have clinical implications if such patients have suboptimal vitamin B 12 status (146)

How to Give a B12 Injection: Self-Administer Guide Knowing how to give a B12 injection at home can turn a routine prescription into a simple, empowering part of your weekly wellness routine