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Inflammation engulfs a substantial amount of oxygen, leading to hypoxia and acidic conditions in the 1 system [13], which subsequently triggers the generation of reactive oxygen species (ROS), angiogenesis, and infiltration by inflammatory cells

(Peptide Sciences) Comparative advantage and specificity Researchers note that many senolytics suffer from off-target cytotoxicity (i.e., they kill healthy cells too)

Iron overload-induced programmed cell death The academic community has consistently recognized the mechanisms related to increased mitochondrial oxidative stress and impaired energy metabolism in the context of iron overload