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13 Passive smokers exhibit elevated urinary cotinine levels, averaging approximately three times higher than that of non-smokers, reported at 13.6 ng/ml in non-smokers, 36.63 ng/ml in passive smokers, and 1043.7 ng/ml in smokers

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Investigations for a very short time period in canine models and long-term cannulated mice exposed to concentrated air particles showed that hypertension was produced and that there was an indication of central sympathetic activation of the neuron system, presumably induced by neuro-inflammation in relation to the disclosure of PM 2.5 (190, 191)