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The earliest stage, Stage 0 represents carcinoma in situ , with abnormal cells confined to the inner lining of the colon or rectum and minimal risk if treated early (10)

The tripeptide sequence glycyl-L-histidyl-L-lysine wraps around a copper ion, creating a structure with remarkable stability when handled correctly and surprising fragility when handled wrong

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For example, some evidence suggests iron overload may contribute to the development of gout, and chlorogenic acids from coffee have been shown to reduce iron absorption