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Generally, iron accumulation induces OS, bringing about the increase of ROS levels and the imbalance of antioxidant balance and infiltrating pro-inflammatory mediators that further amplify cerebral inflammatory responses, which aggravate neuronal damage during reperfusion (Jin et al., 2013

[43] Impaired B 12 absorption can also occur following gastric removal (gastrectomy) or gastric bypass surgery

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Additionally, they found that melittin suppresses inflammatory target gene expression and NF-B activation through the JNK pathway (Xing et al., 2024)