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The method according to claim 1 or 2, the use according to any one of claims 3-6, or the composition according to claim 7 or 8, wherein treatment with the whey protein isolate and/or whey protein concentrate improves at least one of Vineland, CARS, SCQ, CBCL, or ADI-R scores in the subject

In VDR-deficient mice, LCs display a hypermature phenotype characterized by enhanced antigen presentation and proinflammatory features, providing additional evidence that 1,25(OH)D serves as an immune brake in the cutaneous mucosal environment [147, 148]