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Environmental stimuli like sleeping in unfamiliar surroundings, or hearing noises or other sleep interruptions that may lead to partial arousal from sleep

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It has been proposed that ATXN3 is also degraded through autophagy [83], being the mutant (soluble) protein more prone to autophagic degradation, as no changes in endogenous wild-type ATXN3 levels were observed in drug-induced autophagy activation in vivo [84]

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