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A tear in the annulus fibrosus, alongside the degeneration of the nucleus pulposus and the breakdown of the cartilage plate, play roles in the degeneration of the intervertebral disc, which can ultimately result in lumbar disc herniation

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When BPC-157 is used in ex-vivo or cell culture systems, investigators still follow biosafety guidance related to handling human or animal tissues, disposing of biological waste, and documenting any unexpected findings